This area is composed of a ~35 kb iron acquisition segment (the HPI) linked to a ~68 kb pigmentation segment (Buchrieser et al., 1998).
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(1992) and named the pigmentation locus ( pgm). pestis HPI is located in a large unstable area of chromosomal DNA (102-kb) first identified by Fetherston et al. The chromosome of highly pathogenic yersiniae contains a region involved in siderophore-mediated iron acquisition, which is considered a high-pathogenicity island (HPI) (Carniel, 2001). pestis also harboring two other plasmids (pFra and pPst) that are necessary for the expression of complete virulence in this organism (Perry and Fetherston, 1997). All pathogenic strains of Yersinia carry the conserved 70-kb plasmid associated with Yersinia virulence (pYV) which is essential for virulence, with Y. The genus Yersinia ( Enterobacteriaceae) contains 11 species, three of which, pestis (causing bubonic plague) and the enteropathogens pseudotuberculosis and enterocolitica, are pathogenic in humans (Perry and Fetherston, 1997), with plague strains as well as enterocolitica biotype 1B and pseudotuberculosis serogroups I and III also being highly pathogenic in mice (Carniel, 2001). pestis, high pathogenicity island, pgm, psn. These results provide evidence that besides deletion en bloc, specific rearrangements are also involved in the deletion events for that locus. Peru 375 produced previously unreported cultures positive for the pesticin/yersiniabactin outer membrane receptor ( psn+) but negative for the iron-regulated protein ( irp2-), suggesting the occurrence of rearrangements in this chromosomal region and either a sequential loss or the loss of separated segments. Peru 375 dissociated into several phenotypes, PCR analysis showing evidence of changes in the pgm locus of the derived cultures. CE 882 was shown to be highly stable while strains P. pestis isolates using successive subcultures on Congo red agar (CRA) plates. In this work we examined the mobility of HPI and the pigmentation segment in three Y. The pigmentation ( pgm) locus is a large unstable area of the Yersinia pestis chromosome composed of a segment of iron acquisition (HPI) linked to a pigmentation segment. IIUniversidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brazil
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IFundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães, Departamento de Microbiologia, Recife, PE, Brazil Tereza Cristina Leal-Balbino I Nilma Cintra Leal I Mirna Gisele Medeiros do Nascimento I Maria Betânia Melo de Oliveira I Valdir de Queiroz Balbino II Alzira Maria Paiva de Almeida I The pgm locus and pigmentation phenotype in Yersinia pestis Peru 375 produced previously unreported cultures positive for the pesticin/yersiniabactin outer membrane receptor (psn+) but negative for the iron-regulated protein (irp2-), suggesting the occurrence of rearrangements in this chromosomal region and either a sequential loss or the loss of separated segments.
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The pigmentation (pgm) locus is a large unstable area of the Yersinia pestis chromosome composed of a segment of iron acquisition (HPI) linked to a pigmentation segment.